Hovione: Products of Shanghai Shensheng exceed our expectation.
Hovione takes extreme values of safety and convenience of the equipment used. Shanghai Shensheng has provided to its pilot laboratory in Macao with jacketed glass reactor of highest explosion proof level. All electric parts, including stirring motor, frequency converter, thermal sensor and display, are explosion proof. The application of mechanical seal with PTFE lid ensures long term high vacuum level and stirring stableness. The innovative PTFE bottom drain valve ensures no dead space and no leakage.
On the user experience side, Shanghai Shensheng invited the users into the customization design of the equipment and realized the perfect match of the arc of the reactor bottom and the stirring head therefore achieve the goal of decreasing the minimum mix volume to 3% of the total volume. This design was highly appreciated by Hovione, as in the past, when reacting materials decreased from 80L to 5L after a sequence of reactions; they had to be transferred to a 10L or smaller reactor for further reaction as the stirring could not reach fluid surface under 5L. The intermittent reactions are not only time-consuming and labor intensive but also impact on the final result of the reactions.
Moreover, due to the frequent switches of reflux and distillation required by the process, Hovione had to equip the reactor with two independent cooling systems, making the entire reactor setup unecessary compliacted. To tackle this problem, Shanghai Shensheng designed a switching valve at the cooling end, largely facilitated the switch of distillation and reflux of the reactor.
“The performance of the reactor of Shanghai Shensheng exceeds our expectation. This is the first time that we used a reactor made in mainland China. The product quality and safety totally meet the inspection standards and our process requirements. Now materials obtained from different batches are of same quality, which greatly improved our efficiency.” – Workshop Chief of Hovione
Hovione was established in Portugal in 1959 by three Hungarian refugees: Nicholas de Horthy, Andrew Onody and Ivan Villax, thus forming the name Hovione. Hovione is an international Pharmaceutical Company dedicated to helping Pharmaceutical Customers bring new and off-patent drugs to market. With four FDA inspected sites, USA, China, Ireland and Portugal, Hovione offers branded pharmaceutical customers services for the development and compliant manufacture of innovative new drugs including highly potent compounds. For over 50 years, Hovione has been dedicated in the development and compliant manufacture of Active Pharmaceutical Ingredients and Drug Product Intermediates.